Born in 1970 in Alappuzha, Kerala, Zakkir Hussain’s formative years in art, were influenced by the place and its theatre groups. In the late 1980s, he joined 'Samskara', an alternative cultural centre in Eramalloor and the exchange of ideas opened up spaces to engage with the multi layers of cultural representations. Making political posters with other artists stimulated in him the relevance of depicting social and political languages in his works.
He received a degree in painting from the College of Fine Arts, Trivandrum in 1994 and Masters in Graphics from the M.S. University of Baroda in 1997.